Breaking
Revealed! Lagos May Begin Chloroquine Clinical Trial For Coronavirus Treatment Next Week
According to Saturday PUNCH, the Lagos State Government has said it will commence chloroquine clinical trial for the treatment of the novel coronavirus disease within the next one week or thereabouts.
This is sequel to the approval by the National Agency for Food and Drug Administration and Control that chloroquine could be used for the clinical trial treatment of the deadly disease.
There were 386 new cases on Friday, pushing the total cases in the country to 3,912. The number of deaths increased to 117 while 679 persons have been discharged so far.
The state Commissioner for Health, Prof Akin Abayomi, said at a media briefing in Ikeja on Friday that there would be three arms of the trial, capturing treatment, prevention and care for high-risk individuals, like elderly persons with underlying ailments such as hypertension, diabetes and obesity.
Findings by Saturday PUNCH revealed that the state submitted its final protocol to NAFDAC on Thursday evening as it awaits the approval of the agency in preparation for the commencement of the hydroxychloroquine clinical trial treatment next week.
NAFDAC, which approves medicines meant for clinical trials, had on March 20 approved the use of chloroquine for clinical trial treatment of the novel disease, warning however that the approval was not for the drug to be used as a treatment for the virus.
The Director-General, NAFDAC, Prof Mojisola Adeyeye, also confirmed to Saturday PUNCH a few weeks ago that only Lagos State, which has the highest number of cases and is the epicentre of the virus in the country, had signified interest in using the drug for a clinical trial to find treatment for the virus.
And in a recent interview with one of our correspondents, the DG said the state government had sent its protocol to NAFDAC for final approval which would allow it to begin the clinical trial.
She said, “For a clinical trial, you will have to write a protocol and Lagos State submitted its protocol to us. We vetted it back and forth and now they are about to start. It has to be well designed because whatever comes to the scientific world must be defensible. That is the essence of clinical trial treatment planning.
“It has to be well thought out. How many patients will give us a statistical result that will be interpreted well and give a level of confidence? So, these are the kinds of things that go into a clinical trial protocol. We have come alongside Lagos State to review their protocols and they are about to start.”
However, the commissioner said on April 7 that the state had concluded plans to start COVID-19 clinical trial in partnership with the Nigeria Centre for Disease Control and other institutions.
Meanwhile, addressing journalists on Friday, Abayomi said the clinical trials were coming at the most appropriate time given the number of cases the state had been recording in recent times. He noted that the state would use hydroxychloroquine produced by original manufacturers and not the generic one and that the state was set to receive “thousands and thousands of the tablets.”
The number of cases in the state rose by 176 on Friday to 1,667.
He said, “To put together a clinical trial is a very difficult thing; there are people that specialise in clinical trial research. We have to perform the clinical trial in such a way that we would be able to get a very clear result out of it and it won’t have any bias.
“We are planning almost three arms of the hydroxychloroquine trial; one arm of the trial would be for treatment. In other words, if you present with COVID-19 and you test positive, does hydroxyl chloroquine improve your chances of not dying from it or does it shorten the amount of time between when you are diagnosed and when you are cleared of the virus and you are ready to be discharged?
“We are also using it as prevention. For example, if you want to test, when you give the hydroxychloroquine to the health care professionals as prevention, does it protect them from getting infected by COVID-19?
“We also want to use it among people in the communities who have high risk. For example, somebody who is over the age of 70 with hypertension, diabetes or obesity, we know that if you have COVID-19, you are at risk of developing severe to critical symptoms, so if we give members of the public on this clinical trial access to the original hydroxychloroquine, we will protect certain high risk persons from developing or contracting COVID-19.
“These are the arms we are developing in our clinical trial strategy. There is a lot happening around this activity and I think within the next week or so, we would have commenced the trials.”
The commissioner noted that it needed NAFDAC’s permission, ethics approval and recruitment of the participants in the trial.
He added, “As I said, we are still in the early part of the outbreak, so we have a long way to go and the trials are coming in at a time we feel the most appropriate; when we are seeing at least 100 cases a day. It will be easy for us to perform those clinical trials with the number of cases that we are seeing.”
Breaking
Senator Ifeanyi Ubah dies at 52
The Senator representing Anambra South in the National Assembly, Ifeanyi Ubah, is dead.
Ubah, who was the Chief Executive Officer of Capital Oil, was said to have died in a hotel in London, the United Kingdom, on Saturday.
He would have been 53 on September 3.
Senate spokesperson, Yemi Adaramodu, confirmed Ubah’s death to our correspondent on Saturday.
He said, “It’s confirmed, but I am sending an official statement soon.”
Ubah, who was re-elected into the 10th Senate under the Young Peoples Party, had last year defected to the All Progressive Congress.
In September 2022, Ubah escaped assassination when he was attacked by gunmen on his way to Nnewi in Enugwu-Ukwu in Anambra State.
Breaking
JUST IN: Edo state Assembly impeaches Deputy Governor Shaibu
The Edo State House of Assembly, on Monday, impeached the state’s Deputy governor, Comrade Philip Shaibu.
The impeachment followed the adoption of the report of the seven-man investigative panel set up by the Assembly to probe allegations of misconduct against Shaibu.
Breaking
JUST IN: Olubadan of Ibadanland, Oba Lekan Balogun joins ancestors at 81
The Olubadan of Ibadanland, Oba Lekan Balogun has joined his ancestors after a brief illness.
He joined his ancestors at the age of 81.
It was gathered that the late monarch was taken to the hospital Wednesday morning having stayed indoor throughout Tuesday on account of slight malaria fever, though, he was hail and hearty on Monday during which he personally received few guests that paid him congratulatory visits on his second year anniversary on that day.
Making this announcement was the Baba-Kekere Olubadan and his younger brother, Dr Kola Balogun in a statement by the Personal Assistant (Media) to the late monarch, Oladele Ogunsola.
According to the statement, Dr. Balogun disclosed that Oba Balogun would be buried at his Aliiwo ancestral home by 4.00pm on Friday according to Islamic rites just as he said that the State Governor Seyi Makinde, though already verbally informed, would be formally notified early in the morning.
The late Olubadan was the first most educated to have emerged as Ibadan monarch, a British trained P.hd holder, a former university lecturer, former member of management staff of Shell British Petroleum, former gubernatorial candidate of the defunct Nigeria People’s Party, NPP, former Senator and a successful business man.
His last official outing was the Olubadan Advisory Council’s meeting which he presided over last Saturday where the decision to derobed Mogaji Akinsola, Olawale Oladoja was taken.
He however, on Tuesday instructed the Ekerin Olubadan, Oba Hamidu Ajibade to midwife a small committee to deliberate on last Friday’s decision on what should be the position of Ibadan Zone in the proposed newly reconstituted Oyo State Council of Obas and Chiefs.
The decision of the small committee was earlier on Thursday ratified by the Olubadan Advisory Council at a meeting presided over by Otun Olubadan and the former governor of Oyo State, High Chief Rashidi Ladoja and was to be taken to the late Oba Balogun for his signature Friday morning so as to meet the deadline for submission to the state Commissioner for Local Government and Chieftaincy Matters later in the day.
The late Olubadan is survived by wives, children and grandchildren.
Announcing the passage of the monarch, Governor Makinde, in a statement, stated that Olubadan, who joined his ancestors late Thursday evening at the University College Hospital, UCH, Ibadan, described him as an epitome of royal excellence and a great achiever, who made great marks on Ibadanland in just a little over two years of his reign.
He expressed his condolences to the Olubadan-in-Council, the Oyo State Traditional Council and the people of Ibadanland and Oyo State, praying to God to grant repose to the soul of the deceased monarch.
Makinde said: “With total submission to the will of God, I announce the passing unto glory of our father, His Imperial Majesty, Oba Dr. Mohood Lekan Balogun, Alli Okunmade II, the 42nd Olubadan of Ibadanland.
“A mighty Iroko has fallen; Oba Dr. Balogun has joined the ancestors.
“In Kabiyesi, Ibadanland had a cosmopolitan and well-experienced Olubadan, who made indelible marks on the sands of history and achieved greatly within a short while.
“On behalf of the Government and good People of Oyo State, I condole with the immediate family of the Oba Dr. Balogun, the Olubadan-in-Council, the Oyo State Traditional Council and the people of Ibadanland.
“It is my prayer that God grants repose to the soul of our late monarch.”
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