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66-year-old man becomes oldest patient ‘cured of HIV’ after stem cell transplant

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A 66-year-old man, who prefers to remain anonymous, has reportedly been cured of HIV after undergoing a stem cell transplant.

According to a statement by the City of Hope medical center, US, where the procedure took place, the man has been in remission from the virus for over 17 months after stopping antiretroviral therapy (ART) for the disease.

The centre said he is the fourth in the world and the oldest to go into long-term remission of HIV after receiving stem cells from a donor with a rare genetic mutation.

The patient, who was diagnosed with HIV in 1988, was said to have developed acute myelogenous leukemia in 2018, a cancer of the blood and bone marrow. To treat both the cancer and HIV, doctors performed a blood stem cell transplant with cells from a donor who carried a rare genetic mutation that makes people resistant to most strains of HIV infection — the homozygous CCR5 delta 32 mutation.

“CCR5 is a receptor on CD4+ immune cells, and HIV uses that receptor to enter and attack the immune system. But the CCR5 mutation blocks that pathway, which stops HIV from replicating,’ the statement reads.

“The patient received three different therapies to get him into remission before receiving the transplant. Most patients achieve remission after one therapy. The remission is necessary because a transplant is an intensive procedure that can cause serious complications. The patient did not experience serious medical issues after transplant.

“Since recovering from his transplant, the City of Hope patient has not shown any evidence of having replicating HIV virus in his body, either in blood or tissue samples. With institutional review board approval, he stopped taking ART for HIV in March 2021 and was monitored closely for rebound virus. He might have been able to stop the therapies sooner, but wanted to wait until he was vaccinated against COVID-19. City of Hope is continuing to monitor the patient on an ongoing basis.”

Reacting, the patient said when he was diagnosed with HIV in 1988, he thought it was a death sentence.

“I never thought I would live to see the day that I no longer have HIV. City of Hope made that possible, and I am beyond grateful,” he said.

Health

Eating too much meat could cause heart failure in older women

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Women above 50 who consume a lot of protein stand a high risk of heart failure, researchers say.

The risk becomes even more increased when the source of the protein is meat.

Although the study did not prove exactly how a high protein diet affects the health of the heart, postmenopausal women with the most protein in their diet had a 60 percent increased risk of heart failure, as opposed to those who ate little protein, the study found.

Mohomad Firas Barbour, an internist at Brown University’s Alpert medical school and memorial hospital of Rhode Island in Pawtucket, said that most of the risks appear to come from animal protein.

In comparison, the women who got most of their protein from vegetable sources appeared to have a nearly 20 percent reduced risk of heart failure, Barbour said.

“The higher total dietary protein intake, that will increase the risk of heart failure, but higher vegetable protein intake appeared to be protective against heart failure,” he added.

The findings have been presented at the American Heart Association annual meeting in New Orleans, U.S.

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Health

Wrong arm position can result in false blood pressure reading, Study says

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A recent study has found that a wrong arm position during blood pressure (BP) checks may lead to misdiagnosis and overestimation of hypertension.

BP is the pressure of circulating blood against the walls of blood vessels. It is measured in units of millimeters of mercury (mmHg). The reading consists of two numbers — with the upper (systolic) value first, followed by the lower (diastolic) value. A person is considered hypertensive if they have consistent readings of 130/80 or higher.

The new study, published on Monday in Journal JAMA Internal Medicine, analysed the blood pressure readings of 133 adults from August 2022 to June 2023. The study volunteers’ ages ranged from 18 to 80.

The blood pressure readings were measured and compared while the people held their arms in three different ways — leaning on a surface, resting on the lap, or hanging by the side of the body.

The researchers from Johns Hopkins University discovered that when participants had their arms hanging by their sides during the reading, their systolic pressure was 6.5 points higher than when their arms were resting on a desk, while the diastolic blood pressure — the bottom number — was 4.4 points higher than in the supported condition.

The experts also found out that when their arms were on their laps, the systolic blood pressure was 3.9 points higher than when their arms were supported by a surface, while the diastolic pressure was 4 points higher than in the supported condition.

For example, if a person’s actual blood pressure is 134, and blood pressure is measured on a dangling arm, the reading could end up over 140, which is considered to be stage 2 hypertension.

Tammy Brady, the vice-chair for clinical research in the department of pediatrics at the Johns Hopkins University School of Medicine, said the two other positions were tested because it was realised that they are the most used positions during blood pressure readings.

“I did not expect there to be that much of a difference when the arms were placed in the two alternative positions,” he said.

“We tested those positions because those are the positions that most people have their blood pressure measured, according to data and personal observations.

“We thought there’d be a difference, but I was surprised by how much of a difference there was.”

According to the study, the wrong positioning of the arm during BP readings leads to overestimation due to several physiological reasons.

First, there can be muscle contraction when the arm is not supported which can lead to an increase in BP reading.

Also, a greater vertical distance between the heart and where the cuff is placed can increase hydrostatic pressure in the arteries, or the blood pressure against the wall due to gravity’s pull. This can lead to an overestimation of blood pressure.

Brandy said the study was conducted to educate people on the appropriate arm position for BP reading.

“I just hope that it raises awareness regarding how important things like arm position are to blood pressure measurement accuracy,” he added.

“I also hope this study educates patients, empowering them to advocate for proper measurement when they’re in a clinic setting.

“But also, because so many patients rely on home blood pressure measurements for hypertension diagnosis, evaluation, and treatment.

“I hope this educates them on how to properly position their arms because our findings absolutely extend to measurements in the home.”

The researchers also gave the following steps to achieve an accurate BP measurement.

The steps include:

  • Wear the appropriate cuff size
  • Have your back supported
  • Keep feet flat on the floor with legs uncrossed
  • Have the appropriate arm position – the cuff should be positioned at heart level with the arm supported on a desk or table

Wearing the appropriate cuff size was found to be the most important step.

Because an improperly sized blood pressure cuff can distort blood pressure readings taken by automated blood pressure devices.

Also speaking, Gail Adler, a cardiovascular endocrinologist in the Hypertension Clinic at Brigham and Women’s Hospital, disclosed some steps that should taken 30 minutes for BP measurement.

“Before you take your blood pressure, you want no smoking, exercise, caffeine, alcohol, major arguments. Don’t be psychologically stressed,” Adler said.

“Sit in the chair, get in the right position. And for five minutes, you relax, you don’t talk, make sure you don’t have to pee. If you have to pee or urinate, that’s going to raise your blood pressure.”

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NAFDAC warns Nigerians against purchase of unregistered condom brand

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The National Agency for Food and Drug Administration and Control (NAFDAC) has warned Nigerians against sale and distribution of Foula Condoms.

In a statement on Wednesday, the agency said officials from the post-marketing surveillance (PMS) directorate discovered Foula condoms (packaged in threes) in Abakaliki, Ebonyi state, and Zango, Katsina state.

The agency said the condom is not registered by NAFDAC for use in Nigeria, and the labeling of the product is not in English Language.

“Condoms are a proven effective barrier method that can be used as a dual-purpose method for both prevention of unintended pregnancy and protection against HIV and other sexually transmitted infections (STIs),” the statement reads.

“To be most effective, any barrier method used for contraception or preventing infection must be used correctly.

“The illegal distribution or sale of unregistered condoms poses a risk as the safety, quality, and efficacy of the products are not guaranteed.

“The purchase and use of poor-quality condoms will adversely affect every aspect of condom promotion for the prevention of unintended pregnancy and protection against HIV and other Sexually Transmitted Infections.

“If condoms leak or break, they cannot offer adequate protection.

“All NAFDAC zonal directors and state coordinators have been directed to carry out surveillance and mop up the unregistered products within the zones and states.

“Importers, distributors, retailers, healthcare professionals, and consumers are hereby advised to exercise caution and vigilance within the supply chain to avoid the importation, distribution, sale, and use of illegally distributed products.

“All medical products/ medical devices must be obtained from authorized/licensed suppliers. The products’ authenticity and physical condition should be carefully checked.”

“Healthcare professionals and consumers are advised to report any suspicion of the sale of substandard and falsified medicines or medical devices to the nearest NAFDAC office, NAFDAC on 0800-162-3322 or via email: sf.alert@nafdac.gov.ng.”

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Bodex F. Hungbo, SPMIIM is a multiple award-winning Nigerian Digital Media Practitioner, Digital Strategist, PR consultant, Brand and Event Expert, Tv Presenter, Tier-A Blogger/Influencer, and a top cobbler in Nigeria.

She has widespread experiences across different professions and skills, which includes experiences in; Marketing, Media, Broadcasting, Brand and Event Management, Administration and Management with prior stints at MTN, NAPIMS-NNPC, GLOBAL FLEET OIL AND GAS, LTV, Silverbird and a host of others

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